Laboratory

Nanopharmacology and Pharmaceutical Nanoscience

Department

Research Centre of the Centre hospitalier universitaire de Québec – Université Laval (CHUL)

Funding agency(ies)

Centre de recherche – Faculté de Pharmacie de l’Université Laval

Manufacturer (model)

Malvern

Commissioning

2015

Equipment Description

Measurement of the hydrodynamic radius of nanoparticles and colloids by Dynamic Light Scattering (DLS). This technique allows the approximate size of nanoparticles and colloids to be determined based on their interactions with visible light. Through photon correlation spectroscopy, the diffusion coefficient of the colloids is obtained, along with a relative measurement of their size distribution.

This technique relies on several initial assumptions, including Brownian motion and nanoparticle sphericity, and uses physicochemical parameters that may vary between samples, such as solvent viscosity and refractive indices (solvent and colloids).

Technical Specifications

• Maximum sample volume: 50 µL to 3 mL (polystyrene or glass cuvettes)

• Temperature range: 0–60 °C

• Laser: 633 nm (50 mW)

• Solvent compatibility: Aqueous and organic solvents

• Operating pressure: Atmospheric pressure (101 kPa)

• Measurement conditions: Measurements performed in solution (suspensions)

• Analysis time: Approximately 10 minutes per measurement

  
  

Areas of expertise

• Materials Science

• Nanotechnology

• Drug Delivery

Conditions of Use

Training on the instrument is required, or the instrument must be operated by a research professional. Available to academic and/or industrial collaborators.

Rental Fees (CAD)

On-Campus

$50/hour ($75/hour with assistance from a research professional)

Off-Campus (Academic)

$100/hour ($100/hour with assistance from a research professional)

Industry

$150/hour ($150/hour with assistance from a research professional)

Reservations

Nicolas Bertrand

nicolas.bertrand@pha.ulaval.ca

418 656-2131 # 407042